主な研究業績

私たちの医局では下記のような分野の研究を行っております。

基礎研究

1 リウマチ膠原病疾患におけるQOLと心因性因子の解析
2 関節リウマチの複合的レジストリーを用いた多次元的解析
3 全身性エリテマトーデスの疾患レジストリー構築(多施設研究)
4 全身性エリテマトーデスと口腔環境との関連性についての臨床研究

基礎実験ではサイトカインやケモカインなどの生体内分子を中心の研究課題としております。 またさまざまな疾患の疫学および臨床研究なども行っています。 実際の業績は下記、主な研究業績(著書、論文)を参照してください。

臨床研究

1 リウマチ膠原病疾患におけるQOLと心因性因子の解析
2 関節リウマチの複合的レジストリーを用いた多次元的解析
3 全身性エリテマトーデスでの心血管イベントリスクの検討
4 全身性エリテマトーデスに影響する環境因子の検討
5 全身性エリテマトーデスと口腔衛生状態との関連
6 全身性エリテマトーデス患者の診療の質評価

主な研究業績(著書、論文)

年度をクリックすると詳細をご覧いただけます。

2016年度

1 Isozaki T, Nishimi S, Nishimi A, Saito M, Miwa Y, Toyoshima Y, Inagaki K, Kasama T. A disintegrin and metalloproteinase (ADAM)-10 as a predictive factor for tocilizumab effectiveness in rheumatoid arthritis. Mod Rheumatol. 2016 Dec 23:1-5. [Epub ahead of print]
2 Kadoya M, Hida A, Hashimoto Maeda M, Taira K, Ikenaga C, Uchio N, Kubota A, Kaida K, Miwa Y, Kurasawa K, Shimada H, Sonoo M, Chiba A, Shiio Y, Uesaka Y, Sakurai Y, Izumi T, Inoue M, Kwak S, Tsuji S, Shimizu J. Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy. Neurol Neuroimmunol Neuroinflamm. 2016 Oct 7;3(6):e290.
3 Miwa Y, Isojima S, Saito M, Ikari Y, Kobuna M, Hayashi T, Takahashi R, Kasama T, Hosaka M, Sanada K. Comparative Study of Infliximab Therapy and Methotrexate Monotherapy to Improve the Clinical Effect in Rheumatoid Arthritis Patients. Intern Med. 2016;55(18):2581-5.
4 Hida A, Yamashita T, Hosono Y, Inoue M, Kaida K, Kadoya M, Miwa Y, Yajima N, Maezawa R, Arai S, Kurasawa K, Ito K, Shimada H, Iwanami T, Sonoo M, Hatanaka Y, Murayama S, Uchibori A, Chiba A, Aizawa H, Momoo T, Nakae Y, Sakurai Y, Shiio Y, Hashida H, Yoshizawa T, Sakiyama Y, Oda A, Inoue K, Takeuchi S, Iwata NK, Date H, Masuda N, Mikata T, Motoyoshi Y, Uesaka Y, Maeda MH, Nakashima R, Tsuji S, Kwak S, Mimori T, Shimizu J. Anti-TIF1-γ antibody and cancer-associated myositis: A clinicohistopathologic study. Neurology. 2016 Jul 19;87(3):299-308.
5 Kasama T, Isozaki T, Takahashi R, Miwa Y. Clinical effects of tocilizumab on cytokines and immunological factors in patients with rheumatoid arthritis. Int Immunopharmacol. 2016 Jun;35:301-6.
6 Edhayan G, Ohara RA, Stinson WA, Amin MA, Isozaki T, Ha CM, Haines GK 3rd, Morgan R, Campbell PL, Arbab AS, Friday SC, Fox DA, Ruth JH. Inflammatory properties of inhibitor of DNA binding 1 secreted by synovial fibroblasts in rheumatoid arthritis. Arthritis Res Ther. 2016 Apr 12;18:87.
7 Kasama T, Maeoka A, Oguro N. Clinical features of neuropsychiatric syndromes in systemic lupus erythematosus and other connective tissue diseases Clin Med Insights Arthritis Musculoskelet Disord. 2016 Jan 18;9:1-8.
8 AOSDにおけるCXCL10、CXCL13の異常
笠間 毅、林 智樹, 柳井 亮 リウマチ科(0915-227X)56巻3号 Page297-300(2016.09)
9 若年性側頭動脈炎の一例
猪狩 雄蔵、齋藤 麻由, 林 智樹, 西見 慎一郎, 石井 翔, 小鮒 美香, 梅村 方裕, 古屋 秀和, 柳井 亮, 高橋 良, 三輪 裕介
関東リウマチ(0911-4807)49号 Page283-288(2016.03)
9 プライマリ・ケアにおける心身医学の知識とスキルの重要性 山梨県内のプライマリ・ケアにおける心身医学の活用
穂坂 路男, 松島 大輔, 西村 和華, 三輪 裕介
心身医学(0385-0307)56巻11号 Page1083-1089(2016.11)

著書

1 笠間 毅(分担執筆)精神神経症状をみたときに鑑別すべき膠原病 1:検査・症候・臓器障害からみたリウマチ・膠原病診療.リウマチ・膠原病診療ハイグレード リウマチ・膠原病の合併症や諸問題を解く 編集:山岡邦宏、五野貴久.文光堂(東京)2016.1.pp65-75
2 笠間 毅(分担執筆).リウマトイド因子、ANA,抗ミトコンドリア抗体、検査値ガイド.編集:高木 康、市川幾恵.Pp307-309, 2016 総合医学社 東京
3 磯島咲子(分担執筆)【あなたも名医!プライマリケア現場での女性診療 押さえておきたい33のポイント】 (2章)こんなケースはどう診たらいいの? ライフステージ別女性診療 老年期 「背中が痛いんです」。jmed mook47号 Page122-126 (2016.12)

2015年度

1 Isozaki T, Ishii S, Nishimi S, Nishimi A, Oguro N, Seki S, Miura Y, Miwa Y, Oh K, Toyoshima Y, Nakamura M, Inagaki K and Kasama T. A disintegrin and metaroprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis. Transl Res. 2015; 166(3): 244-253.
2 Tokunaga T, Miwa Y, Nishimi A, Nishimi S, Saito M, Oguro N, Miura Y, Ishii S, Takahashi R, Kasama T, and Sanada K; Sex Differences in the Effects of a Biological Drug for Rheumatoid Arthritis on Depressive State. The Open Rheumatology Journal, 2015, 9, 51-56
3 Amin MA, Campbell PL, Ruth JH, Isozaki T, Rabquer BJ, Alex Stinson W, O'Brien M, Edhayan G, Ohara RA, Vargo J, Domino SE, Koch AE. A key role for Fut1-regulated angiogenesis and ICAM-1 expression in K/BxN arthritis. Ann Rheum Dis. 2015 Jul;74(7):1459-66.
4 Ishii S, Miwa Y, Otsuka K, Nishimi S, Nishimi A, Saito M, Miura Y, Oguro N, Tokunaga T, Takahashi R, Kasama T. Influence of renal complications on the efficacy and adverse events of tacrolimus combination therapy in patients with systemic lupus erythematosus (SLE) during a maintenance phase: a single-centre, prospective study. Lupus Sci Med. 2015 May 29;2(1)
5 Ogata A, Amano K, Dobashi H, Inoo M, Ishii T, Kasama T, Kawai S, Kawakami A, Koike T, Miyahara H, Miyamoto T, Munakata Y, Murasawa A, Nishimoto N, Ogawa N, Ojima T, Sano H, Shi K, Shono E, Suematsu E, Takahashi H, Tanaka Y, Tsukamoto H, Nomura A; MUSASHI Study Investigators. Longterm Safety and Efficacy of Subcutaneous Tocilizumab Monotherapy: Results from the 2-year Open-label Extension of the MUSASHI Study. J Rheumatol. 2015 May;42(5):799-809.
6 Umemura M, Miwa Y, Yanai R, Isojima S, Tokunaga T, Tsukamoto H, Takahashi R, Yajima N, Kasama T, Takahashi N, Sueki H, Yamaguchi S, Arai K, Takeuchi Y, Ohike N, Norose T, Yamochi-Onizuka T, Takimoto M. A case of Degos disease: demonstration of C5b-9-mediated vascular injury. Mod Rheumatol. 2015 May;25(3):480-3.
7 Yamanaka H, Nagaoka S, Lee SK, Bae SC, Kasama T, Kobayashi H, Nishioka Y, Ueki Y, Seto Y, Nishinarita M, Tamura N, Kimura N, Saito K, Tomita T, Nawata Y, Suzuki S, Ishigatsubo Y, Munakata Y, Makino Y, Inoue E, Tanaka Y, Takeuchi T; ENCOURAGE study group. Discontinuation of etanercept after achievement of sustained remission in patients with rheumatoid arthritis who initially had moderate disease activity-results from the ENCOURAGE study, a prospective, international, multicenter randomized study. Mod Rheumatol. 2015 Dec 23:1-11. [Epub ahead of print]
8 Odai T, Isozaki T, Kasama T, Ogata H, Kinugasa E. Therapeutic efficacy of leukocytapheresis in a pregnant woman with refractory adult-onset Still's disease. Inter Med. 2015; 54(17): 2261-2266.
8 白馬岳登山における呼吸筋ストレッチ体操と疲労感、呼吸循環パラメータの関連
宝田 千夏, 平岩 三奈, 泉崎 雅彦,三輪 裕介, 小川 良雄
登山医学 2015; 35: 186-190

2014年度

著書

1 Kasama T, Oguro N, Miura Y and Isozaki T. Fractalkine/CX3CL1 and CX3CR1 in rheumatoid arthritis and related conditions. Book; Advances in Medicine and Biology. Volume 75, Chapter6, Editor, Leon V. Berhardt, 2014, pp103-118.

原著

1 Kasama T, Isojima S, Umemura M, Tsukamoto H, Tokunaga T, Furuya H, Yanai R, Takahashi R, Nakamura M, and Inagaki K. Serum macrophage migration inhibitory factor levels are correlated with response to tocilizumab therapy in patients with rheumatoid arthritis. Rheumatol Int 2014; 34: 429-433.
2 Umemura M, Miwa Y, Yanai R, Isojima S, Tokunaga T, Tsukamoto H, Takahashi R, Yajima N, Kasama T, Takahashi N, Sueki H, Yamaguchi S, Arai K, Takeuchi Y, Ohike N, Norose T, Yamochi-Onizuka T, and Takimoto M. A case of Degos disease: demonstration of C5b-9-mediated vascular injury. Mod Rheumatol 2014
3 Takahashi R, Isojima S, Umemura M, Miura Y, Oguro N, Ishii S, Seki S, Tokunaga T, Tsukamoto H, Furuya H, Yanai R, and Kasama T. Serum anti-cyclic citrullinated protein antibody titers are correlated with the response to biological agents in patients with rheumatoid arthritis. Open Access Rheumatology: Research and Reviews 2014:6 57–6.
4 Hirohata S, Kasama T, Kawahito Y and Takabayashi K. Efficacy of anti-ribosomal P protein antibody testing for diagnosis of systemic lupus erythematosus. Mod Rheumatol. 2014
5 Isozaki T, Amin MA, Arbab AS, Koch AE, Ha CM, Edhayan G, Haines GK 3rd, Ruth JH. Inhibitor of DNA binding 1 as a secreted angiogenic transcription factor in rheumatoid arthritis. Arthritis Res Ther. 2014 Mar 13;16(2):R68.
6 Isozaki T, Ruth JH, Amin MA, Campbell PL, Tsou PS, Ha CM, Haines GK 3rd and Koch AE. Fucosyltransferase 1 mediates angiogenesis, cell adhesion and rheumatoid arthritis synovial fibroblast proliferation. Arthritis Res Ther. 2014 Jan 28;16(1):R28.
7 Amin MA, Campbell PL, Ruth JH, Isozaki T, Rabquer BJ, Alex Stinson W, O'Brien M, Edhayan G, Ohara RA, Vargo J, Domino SE, Koch AE. A key role for Fut1-regulated angiogenesis and ICAM-1 expression in K/BxN arthritis. Ann Rheum Dis 2014 :(0)1-8..
8 Isozaki T, Amin MA, Ruth JH, Campbell PL, Tsou PS, Ha CM, Domino SE and Koch AE. Fucosyltransferase 1 mediates angiogenesis in rheumatoid arthritis. Arthritis Rheumatol 2014: 66(8):2047-58.
9 Yoshida K, Korchynskyi O, Tak PP, Isozaki T, Ruth JH, Campbell PL, Baeten DL, Gerlag DM, Amin MA, Koch AE. Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine. Arthritis Rheumatol 2014: 66(10):2716-27.
10 Miwa Y, Nishimi A, Nishimi S, Saito M, Tokunaga T, Yanai R, Takahashi R, Wakabayashi K, Kasama T, and Hosaka M. Combined infliximab and methotrexate treatment improves the depressive state in rheumatoid arthritis patients more effectively than methotrexate alone. Eur J Rheum 2014: 4:147-9.
11 Otsuka K, Miwa Y, Ishii S, Seki S, Miura Y, Oguro N, Isojima S, Tokunaga T, Umemura M, Yanai R, Furuya H, and Kasama T. Steroid-sparing effect of tacrolimus in the maintenance phase of systemic lupus erythematosus: a single-center, prospective study. Clin Exp Med Sci 2014: 2(3): 75-86.
12 Miwa Y, Nishimi A, Nishimi S, Saito M, Ishii S, Seki S, Miura Y, Oguro N, Takahashi R and Kasama T. Cytopenia in Rheumatoid Arthritis Caused by Salazosulfapyridine. Clin Exp Med Sci 2014: 2(3): 97-106.
13 望月健一, 蜂矢るみ, 小川良雄, 三輪裕介. 昭和大学白馬診療所における平成25年度の活動報告と平成3年度調査報告との比較について. 登山医学 2014: 34: 132-135
14 Umemura M, Isozaki T, Ishii S, Seki S, Oguro N, Miura Y, Miwa Y, Nakamura M, Inagaki K and Kasama T. Reduction of serum ADAM17 level accompanied with decreased cytokines after Abatacept therapy in patients with rheumatoid arthritis. Int J Biomed Sci. 2014: 10(4): 229-235.

2013年度

著書

1 Kasama T, Ohtsuka K, Wakabayashi K, Isozaki T and Kobayashi K. Expression and involvement of cytokines, chemokines and adhesion molecules in rheumatoid vasuculitis, Book; Advances in Medicine and Biology. Volume 69, Chapter 3, Editor, Leon V. Berhardt, 2013, pp35-52.
2 笠間毅(分担執筆). III. 治療薬について知る 2.免疫調節薬. 関節リウマチ治療 実践バイブル 編集:竹内勤. 南江堂(東京)2013.5.pp95-100

総説

1 笠間毅:アダリムマブ、特集 関節リウマチーケアからキュアを目指した治療、日本臨床2013;71:1218-1224.

原著

1 Kameda H, Ueki Y, Saito K, Nagaoka S, Hidaka T, Atsumi T, Tsukano M, Kasama T, Shiozawa S, Tanaka Y, Kanbe K, Sato E, Yamanaka H, Takeuchi; Japan Biological Agent Study Integrated Consortium et al.; Japan Biological Agent Integrated Consortium (JBASIC). A merged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study. Ann Rheum Dis. 2013 Feb;72(2):310-2.
2 Miwa Y, Hosaka M, Ohtsuka K, Sato M, Takahashi R, Wakabayashi K, Odai T, Yajima N and Kasama T. Depression in improved when low-dose tacrolumus is given to rheumatoid arthritis patients showing an inadequate response to biologic agents. Mod Rheumatol. 2013; 23:920-24.
3 Furuya H, Kasama T, Isozaki T, Umemura M, Otuka K, Isojima S, Tsukamoto H, Tokunaga T, Yanai R and Takahashi R. Effect of TNF antagonists on the productivity of daily work of patients with rheumatoid arthritis. J Multidiscip Healthc. 2013; 6: 25-30.
4 Tsou PS, Ruth JH, Campbell PL, Isozaki T, Lee S, Marotte H, Domino SE, Koch AE and Amin MA. A novel role for inducible Fut2 in angiogenesis. Angiogenesis. 2013 Jan; 16(1): 195-205.
5 Isozaki T, Rabquer BJ, Ruth JH, Haines GK 3rd and Koch AE. A disintegrin and metalloprotease 10 (ADAM10) is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis. Arthritis Rheum. 2013 Jan; 65(1): 98-108.
6 Isozaki T, Arbab AS, Haas CS, Amin MA, Arendt MD, Koch AE and Ruth JH. Evidence that CXCL16 is a potent mediator of angiogenesis and is involved in endothelial progenitor cell chemotaxis: studies in mice with K/BxN serum-induced arthritis. Arthritis Rheum. 2013 Jul; 65(7): 1736-46.
7 Tsou PS, Ruth JH, Campbell PL, Isozaki T, Lee S, Marotte H, Domino SE, Koch AE and Amin MA. A novel role for inducible Fut2 in angiogenesis. Angiogenesis. 2013 Jan;16(1):195-205.
8 Isozaki T, Rabquer BJ, Ruth JH, Haines GK 3rd andKoch AE.A disintegrin and metalloprotease 10 (ADAM10) is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis. Arthritis Rheum. 2013 Jan;65(1):98-108.
9 Isozaki T, Arbab AS, Haas CS, Amin MA, Arendt MD, Koch AE and Ruth JH. Evidence for CXCL16 as a potent angiogenic mediator and endothelial progenitor cell chemotactic factor. Arthritis Rheum. In press.
10 Kameda H, Kasama T, et al. A merged presentation of clinical and radiographic data using probability plots in a clinical trial, the JESMR study. An Rheum Dis 2013Feb;72(2):310-2.
11 Furuya H, Kasama T, Isozaki T, Umemura M, Otsuka K, Isojima S, Tsukamoto H, Tokunaga T, Yanai R, Takahashi R. Effect of TNF antagonists on the productivity of daily work of patients with rheumatoid arthritis. J Multidiscip Healthc. 2013;6:25-30.
12 Umemura M, Miwa Y, Yanai R, Isojima S, Tokunaga T, Tsukamoto H, Takahashi R, Yajima N, Kasama T, Takahashi N, Sueki H, Yamaguchi S, Arai K, Takeuchi Y, Ohike N, Norose T, Yamochi-Onizuka T, Takimoto M. A case of Degos disease: demonstration of C5b-9-mediated vascular injury. Mod Rheumatol. 2013 (in press).
13 Kasama T, Isojima S, Umemura M, Tsukamoto H, Tokunaga T, Furuya H, Yanai R, Takahashi R, Nakamura M, Inagaki K. Serum macrophage migration inhibitory factor levels are correlated with response to tocilizumab therapy in patients with rheumatoid arthritis. Rheumatol Int 2013 (in press)

2012年度

1 KasamaT, Furuya H, Yanai R, Ohtsuka K, Takahashi R, Yajima N, Miwa Y. Kobayashi K. Correlation of serum CX3CL1 level with disease activity in adult-onset Still's disease and significant involvement in hemophagocytic syndrome. Clin Rheumatol. 2012;31(5):853-60.
2 Kasama T, Umemura M, Isojima S, Isozaki T. Angiogenesis-related cytokines in rheumatoid arthritis. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry” Vol.12, No.4,2012.
3 三輪裕介、穂坂路男、松島大輔、古屋秀和、大塚久美子、佐藤理仁、高橋 良、若林邦伸、小田井 剛、矢嶋宣幸。笠間 毅、真田健史.関節リウマチ患者に対する生物学的製剤の有効性はQOL、抑うつ状態に影響を及ぼすか.心身医学、2012;52:309-314.
4 笠間 毅(分担執筆).膠原病に伴う血液障害 アレルギー・リウマチ膠原病診療最新ガイドライン.Pp256-260, 2012. 総合医学社 東京.
5 三輪裕介、柳井 亮、古屋秀和、笠間 毅(分担執筆).多中心性網状組織球症 アレルギー・リウマチ膠原病診療最新ガイドライン. pp307-309, 2012, 総合医学社,東京
6 Kasama T, Umemura M, Isojima S, Isozaki T. Angiogenesis-related cytokines in rheumatoid arthritis. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry” Vol. 12, No. 4, 2012.
7 Kasama T, Umemura M, Isojima S, Furuya H, Yanai R, Isozaki T. Clinical significance of cytokines and chemokines in neuropsychiatric systemic lupus erythematosus. Current Rheumatology Reviews 2012; 8: 296-306.

2011年度

1 Kameda H, Kanbe K, Kasama T, et al. Continuation of Methotrexate Resulted in Better Clinical and Radiographic Outcomes Than Discontinuation upon Starting Etanercept in Patients with Rheumatoid Arthritis: 52-week Results from the JESMR Study. J Rheumatol. 2011;38:1585-92.
2 Isozaki T, Ohtsuka K, Sato M, Takahashi R, Wakabayashi K, Yajima N, Miwa Y, Kasama T: Synergistic induction of CX3CL1 by interleukin-1 and interferon- in human lung fibroblasts: involvement of signal transducer and activator of transcription 1 signaling pathways. Transl Res. 2011;157:64–70.
3 Wakabayashi K, Sato M, Takahashi R, Odai T, Isozaki T, Yajima N, Miwa Y, and Kasama T. Elevated serum levels of macrophage migration inhibitory factor (MIF) and their significant correlation with rheumatoid vasculitis disease activity. Mod Rheumatol. 2011;22:59-65.
4 Kasama T, Takahashi R, Wakabayashi K, Miwa Y. Clinical relevance of cytokines, chemokines and adhesion molecules in systemic vasculitis. In Book “Advances in the Etiology, Pathogenesis and Pathology of Vasculitis”. chapter 10, edited by: Dr. Luis M Amezcua-Guerra, MD. Publisher; InTech, Rijeka, Croatia. p195-222, 2011.
5 笠間 毅、佐藤理人、高橋 良、CNSループス-病型分類と治療指針、Medical Practice 2011;28:1195-1200.
6 笠間 毅、大塚久美子.新規TNF-α阻害薬ゴリムマブの有効性と安全性.リウマチ科 2011;45:81-87.
7 小田井剛、笠間 毅:アダリムマブ+MTXを用いたPREMIER試験の5年後の結果.リウマチ科 2011;46:5-10.
8 三輪裕介、大塚久美子、佐藤理仁、高橋良、笠間 毅;抗CCP抗体とリウマトイド因子.成人病と生活習慣病 2011;41:39-43.
9 笠間 毅、黒坂大太郎、山田 尚、実地医家における関節リウマチの現状;成人病と生活習慣病 2011;41:7-16.
10 笠間 毅“私の処方”トトレキサート抵抗性関節リウマチに対するミゾリビンの少量間歇併用療法.Modern Physician 2011;31:1019.
11 三輪裕介 “診療の秘訣”所見に見合わない関節痛の訴えがある関節リウマチ患者さんへの対応.Modern Physician 2011;31:1015.
12 笠間 毅“私の処方”トトレキサート抵抗性関節リウマチに対するミゾリビンの少量間歇併用療法.Modern Physician 2011; 31:1019.
13 小田井剛、笠間 毅:アダリムマブ+MTXを用いたPREMIER試験の5年後の結果.リウマチ科 2011;46:5-10.
14 高橋 良、笠間 毅:リウマトイド血管炎.リウマチ科 2011;46:485-489.
15 三輪裕介、柳井 亮、古屋秀和、大塚久美子、笠間 毅.リウマチ性疾患、III.各科疾患における向精神薬の使用法.特集:身体疾患と向精神薬.日本臨床2012;70:99-103.
16 三輪裕介、笠間 毅、穂坂路男、松島大輔.関節リウマチにおける慢性疼痛と抑うつ状態.女性心身医学2012;16:256-259.

2010年度

1 Kasama T, Wakabayashi K, Sato M, Takahashi R, Isozaki T: Critical relevance of the CX3CL1/fractalkine-CX3CR1 pathway in vasculitis and vasculopathy (Review article). Transl Res. 2010;155:20-26.
2 Miwa Y, Muramatsu M, Takahashi R, Wakabayashi K, Odai T, Isozaki T, Yajima N, Kasama T; Dermatomyositis complicated with hemorrhagic shock of the iliopsoas muscle on both sides and the thigh muscle. Mod Rheumatol. 2010;20:420-422.
3 Isozaki T, Kasama T, Wakabayashi K, Sato M, Takahashi R: Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis. Rheumatol Res Rev. 2010;2:29-34.
4 Kasama T, Ohtsuka K, Sato M, Takahashi R, Wakabayashi K, Kobayashi K: Macrophage migration inhibitory factor: a multifunctional cytokine in rheumatic disease. (Review article) Arthritis Volume 2010, Article ID 106202.
5 Isozaki T, Kasama T, Wakabayashi K, Sato K, Takahashi R: Cytokine-mediated regulation of CX3CL1 in osteoblasts from patients with rheumatoid arthritis. Immunol Immunogenet Insight 2010;2:23–29.
6 Isozaki T, Yajima N, Sato M, Takahashi R, Kuninobu Wakabayashi, Miwa Y, Masao Negishi, Hirotsugu Ide, Kasama T,. A case of rheumatoid arthritis with bucillamine-induced yellow nail syndrome initially manifesting as pulmonary. Medicine Insights 2010;4:63–68.
7 Kasama T, Sato M, Takahashi R, Odai T and Kobayashi K; The CX3CL1/CX3CR1 axis is a sensitive marker of the response to anti-TNF therapy in patients with rheumatoid arthritis. (Review article) J Clin Rheumatol Musculoskel Med. 2010;1:19-25.
8 Kasama T, Takahashi R, Sato M and Wakabayashi K. Macrophage inflammatory protein 1 and CCR5 as potential therapeutic targets for HIV infection and acquired immunodeficiency syndrome (Book series “Frontiers in Anti-Infective Drug Discovery”) (Volume 1) 2010;227-237, edited by Prof. M. Iqbal Choudhary and Prof. Atta-ur-Rahman. Bentham Science Publishers.
9 Kameda H, Ueki Y, Kasama T. et al.; Japan Biological Agent Study Integrated Consortium. Etanercept (ETN) with methotrexate (MTX) is better than ETN monotherapy in patients with active rheumatoid arthritis despite MTX therapy: a randomized trial. Mod Rheumatol. 2010;20:531-8.
10 笠間 毅:SLEモデルマウスにおけるCXCL12/CXCR4の過剰発現と治療標的としての可能性.リウマチ科 2010;43:402-406.
11 根岸雅夫、佐藤理仁、高橋 良、若林邦伸、小田井剛、磯崎健男、矢嶋宣幸、三輪裕介、笠間 毅:メトトレキサート療法にエスケープをきたしたRAへの免疫抑制薬の追加併用療法.リウマチ科 2010;43:222-224.
12 笠間 毅:基礎研究と臨床の融合を目指して:昭和大学リウマチ膠原病内科. 分子リウマチ治療 増刊号3、34-34、2010.
13 三輪裕介、佐藤理仁、高橋 良、若林邦伸、小田井 剛、磯崎健男、矢嶋宣幸。笠間 毅、穂坂路雄、エタネルセプト治療による関節リウマチ患者の抑うつ状態改善の機序.臨床リウマチ 2010;22:91-98.
14 笠間 毅、“アダリムマブ”特集:関節リウマチの治療-ベーシックな治療薬と最新薬のハーモニー.Modern Physician 2010;30:1071-1075.
15 磯崎健男、大塚久美子、笠間 毅:ループス腎炎モデルマウスにおけるCXCL3, Th1, Th17.リウマチ科 2010;44:348-353.
16 若林邦伸, 大塚久美子, 笠間毅.【これだけは知っておきたい検査のポイント】免疫学的検査 自己免疫関連検査 抗Jo-1抗体およびそのほかの抗アミノアシルtRNA合成酵素抗体(解説/特集) Medicina 2010;47:454-455.
17 笠間 毅, 佐藤理仁, 高橋良.【これだけは知っておきたい検査のポイント】血液生化学検査 蛋白 補体(解説/特集).Medicina 2010;47:135-137.

2009年度

1 Kasama T, Isozaki T, Sato M, Takahashi R, Wakabayashi K, Tezuka M. Dose-specific biphasic effects of simvastatin on the expression of CXCL10 and CX3CL1 by human osteoblasts. Immunol Immunogenetics Insights 2009:1;29–36.
2 Kasama T, Wakabayashi, Odai T, Isozaki T, Matsunawa M, Yajima N, Miwa Y, Negishi M and Ide H. Effects of low-dose mizoribine pulse therapy in combination with methotrexate in rheumatoid arthritis patients with an insufficient response to methotrexate. Mod Rheumatol. 2009;19:395-400.
3 Matsunawa M, Odai T, Wakabayashi K, Isozaki T, Yajima N, Nohtomi K, Takeuchi H, Miwa Y and Kasama T: Elevated Serum Levels of Soluble CX3CL1 in Patients with Microscopic Polyangiitis. Clin Exp Rheumatol 2009; 27: 72-78.
4 Kanemitsu H, Matsunawa M, Wakabayashi K, Sato M, Takahashi R, Odai T, Isozaki T, Yajima N, Miwa Y, and Kasama T: Increased serum levels of macrophage migration inhibitory factor (MIF) in patients with microscopic polyangiitis. Rheumatol Res Rev. 2009;1:1-8.
5 Odai T, Matsunawa M, Takahashi R, Wakabayashi K, Isozaki T, Yajima N, Miwa Y, and Kasama T: Correlation of CX3CL1 and CX3CR1 levels with response to infliximab therapy in patients with rheumatoid arthritis. J Rheumatol. 2009;36:1158-1165.
6 笠間 毅: 全身性エリテマトーデスにおける妊娠・出産、特集:リウマチ性疾患と妊娠・出産、リウマチ科 2009;42:598-602.
7 笠間 毅: Central nervous system vasculitisの診断と治療、リウマチ科 2009;42:557-563.
8 笠間 毅、矢嶋宣幸、三輪裕介、生物学的製剤の可能性を再考する-自験例を中心に:日本臨床リウマチ学会雑誌 2009;21:370-374.
9 三輪裕介、笠間 毅: 抑うつと睡眠障害.特集:関節リウマチ合併症の診断と対処法.リウマチ科 2009;41:371-377.
10 根岸雅夫、若林邦伸、小田井剛、磯崎健男、矢嶋宣幸、三輪裕介、笠間毅:インフリキシマブ、エタネルセプト治療による関節破壊の改善が認められた2症例.リウマチ科 2009;41:140-142.

2008年度

1 Kasama T, Shiozawa F, Isozaki T, Matsunawa M, Wakabayashi K, Odai T, Yajima N, Miwa Y, Negishi M, and Ide H: Effect of the H2 Receptor Antagonist Nizatidine on Xerostomia in Patients with Primary Sjögren's Syndrome. Mod Rheumatol. 2008;18:455-459.
2 Kasama T, Odai T, Wakabayashi K, Yajima N, Miwa Y: Chemokines in systemic lupus erythematosus involving the central nervous system (Review article). Front Biosci. 2008;13:2527-2536.
3 Kasama T, Isozaki T, Wakabayashi K Odai T and Matsunawa M: Critical Involvement of Cytokines and Chemokines in the Pathogenesis of Rheumatoid Vasculitis (Review article). Clinical Medicine: Arthritis and Musculoskeletal Disorders 2008;2:1-8.
4 Yajima N, Wakabayashi K, Odai T, Isozaki T, Matsunawa M, Miwa Y, Negishi M, Ide H, and Kasama T: Clinical features of hemophagocytic syndrome in patients with dermatomyositis. J Rheumatol. 2008;35:1838-1341
5 Miwa Y, Isozaki T, Wakabayashi K, Odai T, Matsunawa M, Yajima N, Negishi M, Ide H, Kasama T, Adachi M, Hisayuki T, Takemura T: Tacrolimus-induced lung injury in a rheumatoid arthritis patient with interstitial pneumonitis. Mod Rheumatol. 2008;18:208-211.
6 Miwa M, Hosaka M, Wakabayashi K, Odai T, Isozaki T, Matsunawa M, Yajima N, Shiozawa F, Hanaoka R, Negishi M, Ide H, Kasama T, Adachi M; Rheumatoid arthritis patients with Sjögren's syndrome are more prone to depression than patients with rheumatoid arthritis or Sjögren's syndrome alone (Review article). Curr Rheumatol Rev. 2008;4:46-49.
7 Kasama T, Wakabayashi K, Odai T and Isozaki T: Expression and function of angiomodulating cytokines in rheumatoid arthritis and experimental arthritis: important therapeutic targets (Review article). Curr Immunol Rev. 2008;4:159-167.
8 Isozaki T, Kasama T, Odai T, Wakabayashi K, Matsukura S, Adachi M and Tezuka M: Synergistic induction of CX3CL1 by TNF- and IFN- in osteogenic cells from rheumatoid arthritis: Involvement of NF-B and STAT-1 signaling pathways. J Inflam Res. 2008;1:19-28.
9 笠間 毅:関節リウマチの治療の新展開:生物学的製剤治療による新展開.東京都医師会雑誌 2008;61:40-48.
10 三輪裕介、穂坂路男、松島大輔、若林邦伸、小田井剛、松縄瑞穂、矢嶋宣幸、根岸雅夫、井出宏嗣、笠間毅、足立満:Infliximab治療はmethotrexate単独治療と比較してより強力に関節リウマチ患者の抑うつ状態を改善する.心身医学 2008;48:289-295.
11 三輪裕介、大場啓一郎、小田井剛、白井崇生、笠間毅、足立満: 両側胸水貯留、末梢血好酸球増多にて発症した宮崎肺吸虫症の1例. アレルギーの臨床 2008;28:64-68.
12 三輪裕介、穂坂路男、松島大輔、若林邦伸、小田井剛、松縄瑞穂、矢嶋宣幸、根岸雅夫、井出宏嗣、笠間毅、足立満:Infliximab治療による関節リウマチ患者の抑うつ状態改善の機序.心身医学 2008;48:795-801.
13 笠間 毅:全身性エリテマトーデス;膠原病診療の最近の進歩と今後の展望MEDICO誌 2008;39:425-430.
14 根岸雅夫、伊平慶三、若林邦伸、小田井剛、磯崎健男、松縄瑞穂、矢嶋宣幸、三輪裕介、笠間毅:スルファサラジン治療中に顆粒球減少症を発症した関節リウマチの1症例.リウマチ科 2008;39:88-90.

2007年度

1 Kasama T, Isozaki T, Odai T, Matsunawa M, Wakabayashi K, Takeuchi HT, Matsukura S, Adachi M, Tezuka M, and Kobayashi K: Expression of angiopoietin-1 in osteoblasts and its inhibition by tumor necrosis factor alpha and interferon gamma. Transl Res. 2007;149:265-273.
2 Odaka M, Matsukura S, Kuga H, Kokubu F, Kasama T, Kurokawa M, Kawaguchi M, Ieki K, Suzuki S, Watanabe S, Homma T, Takeuchi H, Nohtomi K, Schleimer RP, Adachi M: Differential regulation of chemokine expression by Th1 and Th2 cytokines and mechanisms of eotaxin/CCL-11 expression in human airway smooth muscle cells. Int Arch Allergy Immunol. 2007;143:84-88.
3 Kasama T, Matsunawa M, Wakabayashi K, and Miwa Y: Clinical Relevance of Cytokines and Inflammatory Molecules in Rheumatoid Vasculitis (Review article). Curr Rheumatol Rev. 2007;3:309-316.
4 矢嶋宣幸、小田井剛、笠間 毅:皮膚筋炎に合併するhemophagocytic syndromeの臨床的特徴;リウマチ科 2007;37:117-123.

2006年度

1 Yoda Y, Hanaoka R, Ide H, Isozaki T, Matsunawa M, Yajima N, Shiozawa F, Miwa Y, Negishi M, and Kasama T: Clinical evaluation of patients with inflammatory connective tissue diseases complicated by cytomegalovirus antigenemia. Mod Rheumatol. 2006;16:137-142.
2 Matsunawa M, Isozaki T, Odai T, Yajima N, Takeuchi HT, Negishi M, Ide H, Adachi M, and Kasama T: Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. Arthritis Rheum. 2006;54:3408-3416.
3 Matsukura S, Kokubu F, Kurokawa M, Kawaguchi M, Ieki K, Kuga H, Odaka M, Suzuki S, Watanabe S, Takeuchi H, Kasama T, and Adachi M: Synthetic double-stranded RNA induces multiple genes related to inflammation through Toll-like receptor 3 depending on NF-kappa B and/or IRF-3 in airway epithelial cells. Clin Exp Allergy 2006;36:1049-1062.
4 Kasama T, Isozaki T, Odai T, Matsunawa M, and Yajima N: Expression and function of cytokines and chemokines in neuropsychiatric related systemic lupus erythematosus (Review article). Curr Rheum Rev. 2006;2:177-185.
5 Kasama T, Yajima N, Matsukura S, and Adachi M: Macrophage inflammatory protein 1 and CCR5 as attractive therapeutic targets for HIV infection (Review article). Recent Patents on Anti -Infective Drug Discovery 2006;1:275-280.
6 根岸雅夫、小田井剛、磯崎健男、松縄瑞穂、矢嶋宣幸、依田欣之、塩澤史隆、三輪裕介、笠間 毅、 RAに対するタクロリムス(FK506)の6ヶ月間の評価:リウマチ科, 2006;36:234-236.

2005年度

1 Yajima N, Kasama T, Isozaki T, Odai T, Matsunawa M, Negishi M, Ide H, Kameoka Y, Hirohata S, and Adachi M: Elevated levels of soluble fractalkine in active systemic lupus erythematosus: Potential involvement in neuropsychiatric manifestations. Arthritis Rheum. 2005;52:1670-1675.
2 Kasama T, Yajima N, Shiozawa F, and Hanaoka R: Immunobiology and regulatory mechanisms of the expression of angiogenic and angiostatic factors in arthritis inflammation in New Angiogenesis Research, edited by Zubar, R. V., Nova Science Publishers, New York, USA, 2005, pp257-277.
3 Kasama T: Editolial: The kinetics and profiles of inflammatory cells during inflammatory and allergic responses (Guest Editor: Tsuyoshi Kasama), Curr Drug Targets Inflamm Allergy 2005;4:271.
4 Kasama T, Miwa Y, Isozaki T, Odai T, Adachi M, and Kunkel SL: Neutrophil-derived cytokines: potential therapeutic targets in inflammation (review article). Curr Drug Targets Inflamm Allergy 2005;4:273-279.
5 矢嶋宣幸、笠間 毅、小田井 剛、磯崎健男、松縄瑞穂、塩沢史隆、依田欣之、花岡亮輔、根岸雅夫、井出宏嗣、足立 満:全身性エリテマトーデスにおける血清フラクタルカインについての解析:特に中枢神経病変との関連について;昭和医学会雑誌, 2005;第65巻:174-183.

2004年度

1 Shiozawa F, Kasama T, Yajima N, Odai T, Isozaki T, Matsunawa M, Yoda Y, Negishi M, Ide H, and Adachi M: Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lpr mice. Arthritis Res Ther. 2004;6:R78-86.
2 Kasama T: Collagen-induced arthritis: a useful model for studying the kinetics and regulation of the cytokine network in arthritis development. in Recent Research Developments in Immunology (vol. 5), edited by Pandalai, S. G., Research Signpost, Kerala, India, 2004, pp295-311.
3 根岸雅夫、磯崎健男、松縄瑞穂、依田欣之、矢島宣幸、花岡亮輔、三輪裕介、笠間 毅、井出宏嗣:レフルノミド(アラバ錠)の使用経験;新薬と臨床, 2004;第53巻:489-493.
4 塩澤史隆、笠間 毅、小田井剛、磯崎健男、松縄瑞穂、矢島宣幸、依田欣之、花岡亮輔、井出宏嗣、足立満: 全身性エリテマトーデス(SLE)モデルマウスMRL/lprの肺障害におけるIP-10の関与;昭和医学会雑誌, 2004;第64巻:243-253.
5 根岸雅夫、松縄瑞穂、笠間 毅:薬剤性血管炎とその診断・治療;リウマチ科, 2004;31:488-494.

2003年度

1 Hanaoka R, Kasama T, Muramatsu M, Yajima N, Shiozawa F, Miwa Y, Negishi M, Ide H, Miyaoka H, Uchida H, and Adachi M: A novel mechanism for the regulation of interferon-gamma inducible protein 10 (IP-10) expression in rheumatoid arthritis. Arthritis Res Ther. 2003;5:R74-81.
2 Hanyuda M, Kasama T, Isozaki T, Matsunawa M, Yajima N, Miyaoka H, Uchida H, Kameoka Y, Ide H, and Adachi M: Activated leukocytes express and secrete macrophage inflammatory protein-1α upon interaction with synovial fibroblasts of rheumatoid arthritis via a 2-integrin/ICAM-1 mechanism. Rheumatology (Oxford) 2003;42:1390-1397.
3 根岸雅夫、松縄瑞穂、三輪裕介、笠間 毅:シェーグレン症候群を合併するRA患者の心理状態;リウマチ科, 2003; 29: 467-474.
4 花岡亮輔、笠間 毅、足立 満:関節リウマチにおけるinterferon inducible protein 10の発現と役割.リウマチ科, 2003;29:58-64.

2002年度以前

1 Miwa Y, Yajima N, Shiozawa F, Yoda Y, Hanaoka R, Hanyuda M, Hosaka M, Kasama T, Negishi M, Ide H, and Adachi M: Relationship between psychological factors and arthralgia in patients with rheumatoid arthritis. Mod Rheumatol. 2002;12:32-36.
2 Kasama T, Muramatsu M, Kobayashi K, Yajima N, Shiozawa F, Hanaoka R, Miwa Y, Negishi M, Ide H, and Adachi M: Interaction of monocytes with vascular endothelial cells synergistically induces interferon γ-inducible protein 10 expression through activation of specific cell surface molecules and cytokines. Cell Immunol 2002;219:131-139.
3 Ueda S, Fujiwara N, Naka T, Sakaguchi I, Ozeki Y, Yano I, Kasama T, and Kobayashi K: Structure-activity relationship of mycoloyl glycolipids derived from Rhodococcus sp. 4306. Microb Pathog. 2001;30:91-99.
4 Kobayashi K, Kaneda K, and Kasama T: Immunopathogenesis of delayed-type hypersensitivity (review article). Microsc Res Tech. 2001;53:241-245.
5 Kawasaki S, Takizawa H, Takami K, Desaki M, Okazaki H, Kasama T, Kobayashi K, Yamamoto K, Nakahara K, Tanaka M, Sagai M, and Ohtoshi T: Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001;24:419-426.
6 Kasama T, Shiozawa F, Kobayashi K, Yajima N, Hanyuda M, Takeuchi HT, Mori Y, Negishi M, Ide H, and Adachi M: Vascular endothelial growth factor expression by activated synovial leukocytes in rheumatoid arthritis: Critical involvement of the interaction with synovial fibroblasts. Arthritis Rheum. 2001;44:2512-2524.
7 Desaki M, Takizawa H, Ohtoshi T, Kasama T, Kobayashi K, Sunazuka T, Omura S, Yamamoto K, and Ito K: Erythromycin suppresses nuclear factor-kappa B and activator protein-1 activation in human bronchial epithelial cells. Biochem Biophys Res Commun. 2000;267:124-128.
8 Lu J, Kasama T, Kobayashi K, Yoda Y, Shiozawa F, Hanyuda M, Negishi M, Ide H, and Adachi M: Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis. J Immunol. 2000;164:5922-5927.
9 Kasama T, Kobayashi K, Yajima N, Shiozawa F, Yoda Y, Takeuchi HT, Mori M, Negishi M, Ide H, and Adachi M: Expression of vascular endothelial growth factor by synovial fluid neutrophils in rheumatoid arthritis (RA). Clin Exp Immunol.2000;121:533-538.
10 Kameoka Y, Yamagoe S, Suzuki K, Hatano Y, and Kasama T: Val58Ile polymorphism of the neutrophil chemoattractant LECT2 and rheumatoid arthritis in the Japanase population. Arthritis Rheum. 2000;43:1419-1420.
11 Desaki M, Takizawa H, Kasama T, Kobayashi K, Morita Y, and Yamamoto K: Nuclear factor-kappa B activation in silica-induced interleukin 8 production by human bronchial epithelial cells. Cytokine 2000;12:1257-1260.
12 Kasama T, Yamazaki J, Hatano Y, Kobayashi K, Negishi M, Ide H, and Adachi M: Biphasic regulation by interleukin 12 of the development of murine type II collagen-induced arthritis: Possible involvement of endogenous interleukin 10 and tumor necrosis factor alpha. Arthritis Rheum. 1999;42:100-109.
13 Iwabuchi H, Kasama T, Hanaoka R, Miwa Y, Hatano Y, Kobayashi K, Mori Y, Negishi M, Ide H, and Adachi M: Down-regulation of intercellular adhesion molecule-1 expression on human synovial fibroblasts by endothelin-1. J Rheumatol. 1999;26:522-531.
14 Kasama T, Iwabuchi H, Hanaoka R, Takeuchi HT, Miwa Y, Lu J, Mori Y, Kobayashi K, Negishi M, Ide H, and Adachi M: Synovial fluid neutrophil expression of interleukin 8 in rheumatoid arthritis. Jpn J Rheum. 1999;9:175-187.
15 Hatano Y, Kasama T, Iwabuchi H, Hanaoka R, Takeuchi HT, Lu J, Mori Y, Kobayashi K, Negishi M, Ide H, and Adachi M: Macrophage inflammatory protein 1 alpha expression by synovial fluid neutrophils in rheumatoid arthritis. Ann Rheum Dis 1999;58:297-302.
16 Takizawa H, Ohtoshi T, Kawasaki S, Kohyama T, Desaki M, Kasama T, Kobayashi K, Nakahara K, Yamamoto K, Matsushima K, and Kudoh S: Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: Importance in cytokine transcription. J Immunol. 1999;162:4705-4711.
17 Ohta TM, Kasama T, Hanyuuda M, Hatano Y, Kobayashi K, Negishi M, Ide H, and Adachi M: Interleukin 13 down-regulates the expression of neutrophil-derived macrophage inflammatory protein-1 alpha. Inflamm Res. 1998;47:361-368.
18 Kawasaki S, Takizawa H, Ohtoshi T, Takeuchi N, Kohyama T, Nakamura H, Kasama T, Kobayashi K, Nakahara K, Morita Y, and Yamamoto K: Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro. Antimicrob Agents Chemother. 1998;42:1499-1502.
19 Kobayashi K, Kai M, Gidoh M, Nakata N, Endoh M, Singh RP, Kasama T, and Saito H: The possible role of interleukin (IL)-12 and interferon-γ-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice. Clin Immunol Immunopathol. 1998;88:226-231.
20 Takizawa H, Desaki M, Ohtoshi T, Kawasaki S, KohyamaT, Sato M, Tanaka M, Kasama T, Kobayashi K, Nakajima J, and Ito K: Erythromycin modulates IL-8 expression and inflamed human bronchial epithelial cells. Am J Respir Crit Care Med. 1997;156:266-271.
21 Kobayashi K, Nakata N, Kai M, Kasama T, Hanyuda Y, and Hatano Y: Decreased expression of cytokines that induce type 1 helper Tcell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium. Clin Immunol Immunopathol. 1997;85:112-116.
22 Kobayashi K, Yamazaki J, Kasama T, Katsura T, Kasahara K, Wolf SF, and Shimamura T: Interleukin-12 deficiency in susceptible mice infected with Mycobacterium avium and amelioration of established infection by interleukin-12 replacement therapy. J Infect Dis. 1996;174:564-573.
23 Kunkel SL, Lukacs NW, Kasama T, and Strieter RM: The role of chemokines in inflammatory joint disease (review article). J Leukoc Biol. 1996;58:6-12.
24 Kasama T, Strieter RM, Lukacs NW, Burdick MD, and Kunkel SL: Interferon gamma modulates the expression of neutrophil-derived chemokines. J Investig Med. 1995;43:58-67.
25 Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD, and Kunkel SL: Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest. 1995;95:2868-2876.
26 Kobayashi K, Kasama T, Yamazaki J, Hosaka M, Katsura T, Mochizuki T, Soejima K, and Nakamura RM: Protection of mice from Mycobacterium avium infection by recombinant interleukin-12. Antimicrob Agents Chemother. 1995;39:1369-1371.
27 Kunkel SL, Standiford TJ, Kasama T, and Strieter RM: Chemotactic cytokines: The Chemokine Family. in, Pulmonary Fibrosis Lung Biology in Health and Disease (Eds) Phan, S.H., and Thrall, R.S., Marcell Dekker, New York, NY, 1995, pp579-597.
28 Kasama T, Strieter RM, Lukacs NW, Burdick MD, and Kunkel SL: Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol. 1994;152:3559-3569.
29 Kunkel SL, Lukacs NW, Kasama T, and Strieter RM: Chemotactic cytokines. in Cytokines in Infection, edited by Griffin, G.E., Baillere Tindall, London, United Kingdom, 1994, pp 25-36.
30 Kunkel SL, Lukacs NW, Kasama T, and Strieter RM: The expression of chemokines and their role in leukocyte recruitment. in Molecular Basis of Inflammation, in Challenges of Modern Medicine, edited by Navarro, J., Ares-Serono Symposia Publications, Rome, Italy, 1994, pp 45-58.
31 Kasama T, Strieter RM, Standiford TJ, Burdick MD, and Kunkel SL: Expression and regulation of human neutrophil-derived macrophage inflammatory protein-1 alpha (MIP-1α). J Exp Med. 1993;178:63-72.
32 Katsura T, Kobayashi K, Hosaka M, Sugihara S, Kasama T, Kasahara K, Cohen S, and Yoshida T: Desensitization of deladed-type hypersensitivity in mice: suppressive environment. Med Inflamm. 1993;2:205-210.
33 Hashimoto M, Kobayashi K, Yamagata N, Katsura T, Sugihara S, Iwabuchi H, Kasama T, Kasahara K, Takahashi T, and Takeshita K: Suppression of pulmonary granulomatous inflammation by immunomodulating agents. Agents Actions 1992;37:99-106.
34 Kasama T, Kobayashi K, Yamagata N, Matsuda T, Kasahara K, and Takahashi T: Suppression of pulmonary hypersensitivity granulomas in mice by superoxide dismutase. Immunopharmacology 1992;23:3-13.
35 Kasama T, Kobayashi K, Yamagata N, Iwabuchi H, Matsuda T, Nakatani K, Kasahara K, and Takahashi T: Augmentation of pulmonary foreign body granulomatous inflammation in mice by lipopolysaccharide: involvement of macrophage activation and tumor necrosis factor-alpha. Int Arch Allergy Appl Immunol. 1992;97:130-138.
36 Kobayashi K, Yamagata N, Iwabuchi H, Katsura T, Sugihara S, Kasama T, Kasahara K, and Takahashi T: In vivo roles of cytokines in granulomatous inflammations. Adv Allergy Immunol. 1992;1:57-70.
37 Sato IY, Kobayashi K, Yamagata N, Shikama Y, Kasama T, Kasahara K, and Takahashi T: Modulation of granuloma formation in vitro by endogenous mediators. Immunopharmacology 1991;21;73-82.
38 Kaga S, Kobayashi K, Yamagata N, Takeuchi HT, Yoshida K, Matsuda T, Nakatani K, Kasama T, Kasahara K, and Takahashi T: Lysosomal enzyme activities in experimental granulomatous inflammation. Int Arch Allergy Appl Immunol. 1991;95:236-243.
39 Tabata M, Kobayashi K, Kaga S, Hashimoto M, Kasama T, Fukushima T, Yoshida K, Yamagata N, Sekine F, Ohno I, Negishi M, Ide H, and Takahashi T: Antibodies to interleukin 2 in sera of autoimmune-prone mice. Scand J Rheumatol. 1990;19:183-188.
40 Sato IY, Kobayashi K, Kasama T, Kaga S, Kasahara K, Kanemitsu H, Nakatani K, Takahashi T, Nakamura RM, Skamene E, and Yoshida T: Regulation of Mycobacterium bovis BCG and foreign body granulomas in mice by the Bcg gene. Infect Immunol. 1990;58:1210-1216.
41 Kasama T, Kobayashi K, Kanemitsu H, Nakatani K, Kaga S, Hashimoto M, Yoshida K, Yamagata N, Fukushima T, Tabata M, Negishi M, Ide H, Takahashi T, and Niwa Y: Involvement of interleukin-1-like factor(s) in type II collagen-induced arthritis in mice. Immunol Lett. 1990;26;171-175.
42 Ohnishi T, Nakajima H, Kasama T, Noguchi H, Ide H, Takahashi T, and Niwa Y: Lipidperoxide, superoxide dismutase, catalase, and glutathion peroxiperoxidase in lung carcinoma tissue. Showa Univ J Med Sci. 1990;1:65-70.
43 Niwa Y, Kasama T, Miyachi Y, and Kanoh T: Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: Cross-sectional and longitudinal studies. Life Sci. 1989;44:1655-1664.
44 Kasama T, Kobayashi K, Fukushima T, Tabata M, Ohno I, Negishi M, Ide H, Takahashi T, and Niwa Y: Production of interleukin-1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: The role of interleukin 1 and reactive oxygen species in inflamed sites. Clin Immunol Immunopathol. 1989;53:439-448.
45 Yamagata N, Kobayashi K, Kasama T, Fukushima T, Tabata M, Yoneya I, Shikama Y, Kaga S, Hashimoto M, Yoshida K, Sekine F, Negishi M, Ide H, Mori Y, and Takahashi T: Multiple cytokine activities and loss of interleukin 2 inhibitor in synovial fluids of patients with rheumatoid arthritis. J Rheumatol. 1988;15:1623-1627.
46 Niwa Y, Kanoh T, Kasama T, and Negishi M: Activation of antioxidant activity in natural medicinal products by heating, brewing and lipophilization. A new drug delivery system. Drug Exp Clin Res. 1988;14:361-372.
47 Kasama T, Kobayashi K, Sekine F, Negishi M, Ide H, Takahashi T, and Niwa Y: Follow-up study of lipid peroxides, superoxide dismutase and glutathione peroxidase in the synovial membrane, serum and liver of young and old mice with collagen-induced arthritis. Life Sci. 1988;43:1887-1896.
48 Fukushima T, Kobayashi K, Kasama T, Kasahara K, Tabata M, Sekine F, Negishi M, Ide H, and Takahashi T: Inhibition of interleukin 2 by serum in healthy individuals and patients with autoimmune disease. Int Arch Allergy Immunol. 1987;84:135-141.
49 Kobayashi K, Kasama T, Fukushima T, Kasahara K, Tabata M, Sekine F, Negishi M, Ide H, and Takahashi T: Deficiency of interleukin 2 inhibitor activity in serum from autoimmune-prone mice. Immunol Invest. 1987;16:45-55.
50 Niwa Y, Kasama T, Kawai S, Komura J, Sakane T, Kanoh T, and Miyachi Y.: The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns. Life Sci. 1987;42:351-356.

私たちと一緒に学びませんか?

医局員募集要項はこちら


昭和大学病院
〒142-8666 東京都品川区旗の台1-5-8
アクセスマップ
電話:03-3784-8000(代表)

[初 診]月曜~土曜 8:00~11:00
[再 診]月曜~土曜 8:00~11:00(予約のない方)
[休診日] 日曜日、祝日、創立記念日(11月15日)、年末年始